San Francisco 49ers schedule for the 2021 NFL season

Here is a week-by-week look at the 2021 NFL schedule for the San Francisco 49ers:

Sept. 12 – at Detroit Lions, 1 p.m. ET (FOX)

Sept. 19 – at Philadelphia Eagles, 1 p.m. ET (FOX)

Sept. 26 – Green Bay Packers, 8:20 p.m. ET (NBC)

Oct. 3 – Seattle Seahawks, 4:05 p.m. ET (FOX)

Oct. 10 – at Arizona Cardinals, 4:25 p.m. ET (FOX)

Oct. 24 – Indianapolis Colts, 8:20 p.m. ET (NBC)

Oct. 31 – at Chicago Bears, 1 p.m. ET (FOX)

Nov. 7 – Arizona Cardinals, 4:25 p.m. ET (FOX)

Nov. 15 – Los Angeles Rams (Monday), 8:15 p.m. ET (ESPN)

Nov. 21 – at Jacksonville Jaguars, 1 p.m. ET (FOX)

Nov. 28 – Minnesota Vikings, 4:25 p.m. ET (FOX)

Dec. 5 – at Seattle Seahawks, 8:20 p.m. ET (NBC)

Dec. 12 – at Cincinnati Bengals, 1 p.m. ET (CBS)

Dec. 19 – Atlanta Falcons, 4:05 p.m. ET (CBS)

Dec. 23 – at Tennessee Titans (Thursday), 8:20 p.m. ET (NFLN)

Jan. 2 – Houston Texans, 4:05 p.m. ET (CBS)

Jan. 9 – at Los Angeles Rams, 4:25 p.m. ET (FOX)

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